872
chapter 36
Biochemistry of Hemostasis
as described in F. C. Bernstein, T. F. K oetzle, G. J. B.
W illiam s, E. F. M eyer, Jr., M . D . B rice, J. R. R odgers,
O.
Kennard, T.
Shim anouchi, and M . Tasum i, “The
Protein D ata Bank: A Com puter-based A rchival File
for M acrom olecular Structures”, ./.
Mol. Biol.,
112,
5 3 5 -5 4 2 (1977). G ene inform ation has been obtained
from GenBank: Burks, C ., C assidy, M ., Cinkosky, M . J.,
C um ella, K. E., G ilna, P., H ayden, J. E -D ., Keen, G. M .,
K elley, T. A ., K elly, M ., K ristofferson, D ., and R yals,
J. G enBank. N ucl. A cid s R es. 19(Suppl), 2 2 2 1 -2 2 2 5
(1991). For the coordinates o f the m olecules for w hich
structures are show n see http://w w w .rcsb.org/. The author
thanks Jam es G. W hite, M.
D ., R egents’
Professor,
U niversity o f M innesota, M inneapolis, M innesota for
the photographs o f platelets and M eir R igbi, Professor
Em eritus, Hebrew U niversity o f Jerusalem for his many
helpful com m ents on the manuscript.
Supplemental Readings and References
R. D. Appleby and R. J. Olds: The inherited basis of venous thrombosis.
P a th o lo g y
29, 341 (1997).
D. W. Banner: The factor Vlla/tissue factor complex.
T h ro m b o sis a n d
H a e m o sta sis
78, 512(1997).
K. A. Bauer: New markers for
in vivo
coagulation.
C u rren t O p in io n s in
H em a to lo g y
1, 341 (1994).
W. Bode and M. T. Stubbs: Spatial structure of thrombin as a guide to its
multiple sites of interaction.
S em in a rs in T h ro m b o sis a n d H em o sta sis
19,
321 (1993).
R. Carrell, D. Lomas, R Stein, and J. Whisstock: Dysfunctional variants and
the structural biology of the serpins.
A d v a n c e s in E xp erim en ta l M ed icin e
a n d B io lo g y
425, 207 (1997).
D. Collen and H. R. Lijnen: Molecular basis of fibrinolysis, as relevant for
thrombolytic therapy.
T h ro m b o sis a n d H a e m o sta sis
74, 167 (1995).
R. A. Engh, R. Huber, W. Bode, and A. J. Schulze: Divining the serpin inhi-
bition mechanism, a suicide substrate “spring?”
Trends in B io tech n o lo g y
13,503 (1995).
T. Halkier:
M e c h a n ism s in B lo o d C o a g u la tio n F ib rin o lysis a n d the
C o m p lem e n t System .
Cambridge University Press, Cambridge, 1991,
pp. 466.
C. M. Jackson: Hemostasis and blood coagulation,
E n cyclo p ed ia o f H u m a n
B io lo g y,
R. Dulbecco, (Ed), Academic Press, Inc., San Diego, Vol. 2,
Second Edition 23 (1997).
M. Kalafatis, J. O. Egan, V. K. M. van Cawthern, and K. G. Mann: The regu-
lation of clotting factors.
C ritica l R eview s o f E u k a ryo tic G ene E xpression
7,241 (1997).
H P. Kohler and P. J. Grant: Plasminogen-activator inhibitor type 1 and
coronary artery disease.
N ew E n g la n d J o u rn a l o f M ed icin e
342, 1792
(
2000
).
D. A. Lane and P. J. Grant: Role of hemostatic gene polymorphisms in venous
and arterial thrombotic disease.
B lo o d
95, 1517 (2000).
H. R. Lijnen and D. Collen: Mechanisms of physiological fibrinolysis.
B ail-
lieres C lin ica l H a em a to lo g y
8, 277-290 (1995).
J. P. Miletich: Thrombophilia as a multigenic disorder.
S em in a rs in T hrom -
b o sis a n d H em o sta sis
24 Supplement 1, 13 (1998).
M. W. Mosesson: Fibrinogen structure and fibrin clot assembly.
Sem in a rs in
T h ro m b o sis a n d H em o sta sis
24, 169 (1998).
Y. Nemerson and P. L. Giesen: Some thoughts about localization
and expression of tissue factor.
B lo o d C o a g u la tio n a n d F ibrinolysis
9(Suppl. 1), S45 (1998).
S. T. Olson and I. Bjork: Regulation of thrombin activity by antithrom-
bin and heparin.
S em in a rs in T h ro m b o sis a n d H a em o sta sis
20, 373
(1994).
S. I. Rapaport and L. V. Rao: The tissue factor pathway, how it has become
a “prima ballerina”.
T h ro m b o sis a n d H a em o sta sis
74,7 (1995).
J. Rosing, H. C. Hemker, and G. Tans: Molecular biology and pathophysiol-
ogy of APC resistance, current insights and clinical implications.
S em in a rs
in T h ro m b o sis a n d H a e m o sta sis
24, 329 (1998).
Z. M. Ruggeri: Mechanisms initiating platelet thrombus formation.
T hrom -
b o sis a n d H a em o sta sis
78, 611 (1997) [published erratum appears in
T h ro m b o sis a n d H a em o sta sis
78, 1304 (1997)] [see comments],
J. E. Sadler: Biochemistry and genetics of von Willebrand factor.
A n n u a l
R eview s o f B io ch em istry
67, 395 (1998).
A. H. Schmaier: Contact activation, a revision.
T h ro m b o sis a n d H aem ostasis
78, 101 (1997).
M. T. Stubbs and W. Bode: A player of many parts, the spotlight falls on
thrombin’s structure.
T h ro m b o sis R esea rch
69, 1
(1993).
M. T. Stubbs, M. Renatus, and W. Bode: An active zymogen, unraveling the
mystery of tissue-type plasminogen activator.
B io lo g ica l C h em istry
379,
95 (1998).
J. W. Suttie: Synthesis of vitamin K-dependent proteins.
F A SEB J o u rn a l
7,
(1993).
R. F. Zwaal, P. Comfurius, and E. M. Revers: Lipid-protein interactions in
blood coagulation.
B io ch im ica e t B io p h ysica A c ta
376, 433 (1998).
A. L. Bloom, C. D. Forbes, D. P. Thomas, and E. G. D. Tuddenham (Eds):
H a em o sta sis a n d T h ro m b o sis,
3rd ed. Churchill Livingstone, New York,
1994, p. 1477.
R. Colman, J. Hirsch, V. Marder, and E. Salzman (Eds):
H em o sta sis-a n d
T h ro m b o sis,
3rd ed. J. B. Lippincott, Philadelphia, 1995, p. 1025.
J. Jespersen, R. M. Bertina, and F. Haverkate (Eds):
L a b o ra to ry Techniques
in T hrom bosis: A M anual,
2nd ed. Kluwer Academic, Dordrecht, 1999,
p. 308.
previous page 905 Bhagavan Medical Biochemistry 2001 read online next page 907 Bhagavan Medical Biochemistry 2001 read online Home Toggle text on/off